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Effect of lacosamide on the quality of life of patients with epilepsy

A. García-Escrivá, N. López-Hernández, V. Llorca, A. Alfaro, M. Asensio-Asensio, C. García, M. Lezcano-Rodas, V. Medrano, S. Palao [REV NEUROL 2014;59:145-152] PMID: 25059264 DOI: https://doi.org/10.33588/rn.5904.2014106

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Volumen 59 | Number 04 | Nº of views of the article 10.014 | Nº of PDF downloads 731 | Article publication date 16/08/2014

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ABSTRACT

INTRODUCTION Epilepsy causes psychiatric disorders in 20-40% of patients impacting negatively on their quality of life. Lacosamide is a new antiepileptic as adjunctive therapy in partial seizures with or without generalization.

AIM We conducted a study to assess the impact of lacosamide as to the quality of life of epileptic patients. We used the HAD scale for anxiety and depression and QOLIE-10 scale for quality of life. We evaluated the efficacy and tolerability.

PATIENTS AND METHODS We collected prospectively poorly controlled epileptic patients are and added lacosamide treatment. Baseline visit, at 3 and 6 months were performed. The questionnaires are completed and the epilepsy information has been collected.

RESULTS 31 patients, age 45.5 ± 17.2 years, 64.5% males are included. Number of previous monthly crisis 1.6 ± 1.8. HAD anxiety scale shows a significant improvement at 3 and 6 months. HAD scale for depression reflects a significant improvement in quality parameters. QOLIE-10 shows significant improvement for the group with low quality of life after 3 and 6 months. After 6 months 61.3% of patients have a seizure reduction equal or more than 50% and 54.8% are seizure free. Dizziness is the most common side effect (22.8%). 74.2% continued treatment.

CONCLUSIONS Lacosamide may improve anxiety, depression and quality of life of epileptic patients regardless of seizure control. Response to treatment, adherence and side effects are similar to previous studies. KeywordsAnxiety Depression Effectiveness Epilepsy Lacosamide CategoriesCalidad, Gestión y Organización Asistencial Epilepsias y síndromes epilépticos Neuropsiquiatría

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Effect of lacosamide on the quality of life of patients with epilepsy

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