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Prevalence of antiparkinsonian treatment complications: a systematic review and estimation of projections
INTRODUCTION. The development of Parkinson’s disease (PD) presents different complications deriving from the disease itself, but also from its treatment. The appearance of side effects with the use of antiparkinsonian drugs is common and their management is complicated, which makes it necessary to determine the epidemiological impact of these problems related with antiparkinsonian medication.
AIM. To estimate the prevalence of the side effects of the treatment for the motor symptoms of PD and the possible long-term impact.
PATIENTS AND METHODS. A systematic review was performed in the biomedical databases since the year 2004; the most relevant studies were selected and the frequencies of the most common side effects were identified. The data thus obtained were projected in order to estimate their impact in the long term.
RESULTS. Altogether 218 studies were identified, of which 24 were selected for the review. Data were obtained for 20 types of complications deriving from the antiparkinsonian treatment, including heart problems, oedemas and neuropsychiatric symptoms.