Lipids and lipoproteins in a group of patients with ischemic cerebrovascular disease
Objective. To study the blood levels of a group of lipids and lipoproteins in patients with ischemic cerebrovascular disease which was not secondary to cardiac embolic disease. Patients and methods. We assessed 40 patients of an average age of 64.5 years. Of these, 26 had cerebral infarcts due to disease of the great vessels and 14 had lacunar infarcts. Forty persons with no cerebrovascular disease were used as controls. We excluded patients diagnosed as having renal failure, liver, hematological, neoplastic and acute febrile disorders. Plasma was analyzed for total cholesterol, triglycerides, lipoproteins (a), HDL, LDL, VLDL and apoprotein B between 3 weeks and 6 months after the initial stroke. Results and conclusions. Levels of triglycerides and of lipoprotein (a) were significantly greater in patients than in controls. We found no differences between the levels of total cholesterol, HDL, LDL, VLDL in the three groups studied. However, apoprotein B was greater in the controls than in the patients. There were no significant differences between the groups with lacunar ictus and those with infarcts secondary to disease of the great vessels
Pacientes y métodos Evaluamos 40 enfermos con una edad media de 64,5 años, 26 con infartos cerebrales por afectación de grandes vasos y 14 con infartos lacunares, así como 40 sujetos sin enfermedad cerebrovascular que fueron tomados como controles. Fueron excluidos aquellos pacientes con diagnóstico de insuficiencia renal, afecciones hepáticas, hematológicas, neoplásicas y estados febriles agudos. Las determinaciones hemáticas de colesterol total, triglicéridos, lipoproteína (a), HDL, LDL, VLDL y apoproteína B fueron realizadas entre las 3 semanas y los 6 meses del ictus inicial. Resultados y conclusiones. Los niveles de triglicéridos y de la Lp (a) resultaron significativamente mayores en los pacientes respecto a los controles. No encontramos diferencias entre las concentraciones de colesterol total, HDL, LDL, VLDL en los tres grupos de estudio; sin embargo, la apoproteína B fue mayor en los controles respecto a los pacientes. No existieron diferencias significativas entre el grupo con ictus lacunares y el de infartos por afectación de grandes vasos
